VELEZ-MITCHELL: Then she stays overnight. You go to the derby on Sunday, the day she goes missing. VELEZ-MITCHELL: Wait, that was - that was - OK, so she spends the night with you. And Hunter took her home about - left her house about 5. Just stayed around and had a lazy afternoon. And after that was over, we all came home. We all left together at 3:30 to go to the Dewitt (ph) Derby. TRACEY SNYDER, MOTHER OF CASSIE`S BEST FRIEND (via phone): Well, my friend (ph) left her home and picked Cassie up Saturday afternoon about 1:30, brought her to her house. Cassie had stayed at your house the night before she vanished, so let`s start by telling us about the 24 hours leading up to Cassie`s disappearance. I know you`re doing everything you can to find this young lady. Tracey, thank you so much for joining us tonight. And first, I want to go out to my primetime exclusive guest, the mother of Cassie`s best friend, Tracey Snyder. Go to my Jane Velez- Mitchell Facebook page or you can talk to me on Twitter, Our expert Lion`s Den standing by. (END VIDEO CLIP) VELEZ-MITCHELL: What do you think happened? Call me: 1-877-JVM-SAYS, 1- 87. (BEGIN VIDEO CLIP) UNIDENTIFIED FEMALE: I`m so scared somebody kidnapped her. Cassie`s family is terrified that she was abducted. After Cassie walked out the front door, she vanished. But less than 30 minutes after getting home, cops say Cassie texted her best friend, saying she was going out to buy a pack of cigarettes. Cassie`s mom allegedly told investigators that the teen had arrived home Sunday evening after spending the night at a friend`s house. (END VIDEOTAPE) VELEZ-MITCHELL: Cops say 15-year-old Cassie Compton was last seen leaving her family`s Arkansas home almost exactly one month ago. UNIDENTIFIED FEMALE: There`s just so many unanswered questions with her. UNIDENTIFIED MALE: She was gone like a whisper in the wind. She was home only for a short time before she walked out the door. UNIDENTIFIED FEMALE: She came home from the Derby in Dewitt with her friend Hunter. UNIDENTIFIED FEMALE: Fifteen-year-old Cassie Compton is still missing. (BEGIN VIDEOTAPE) UNIDENTIFIED FEMALE: She`s basically vanished. I`m Jane Velez-Mitchell, coming to you live. Did these cops waste precious time but not issuing an Amber Alert for precious Cassie? Good evening. Cops say 15-year-old Cassie Compton walked out her front door, telling a friend she wanted to buy cigarettes, and this young lady simply vanished into thin air. JANE VELEZ-MITCHELL, HOST: Tonight, breaking news in a race against time in the mysterious, frightening disappearance of a beautiful Arkansas teenager. please join us next time for another edition of "WHAT WOULD YOU DO?" on HLN. JOHN QUINONES, ABC NEWS: I`m John Quinones with ABC News. THIS COPY MAY NOT BE IN ITS FINAL FORM AND MAY BE UPDATED. Where is Cassie Compton? Police Issue Warrant for Taser Victim`s Arrest Adopt-a-Dog Month
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If you are limited with location options or are not sure which spot will look pretty in pictures – consult your photographer. You can create a gallery of visuals using either the Pinterest app, saving images within Instagram, or just by saving all your favorite pictures to the phone. One of the first steps in getting ready for any photo session is gathering inspiration images into a mood board. It’s much easier to prepare for the session if you have a clear idea and vision of the images you are looking to get from your photoshoot. Some of the most important factors are the location choice, suitable outfits, and the photoshoot theme. Want to have a successful and unforgettable couple photoshoot? You’ve got to prepare for it properly. You can see more of our photography style and portfolio here. If you are looking for a couple’s portrait photographer in the Sacramento, California area, Bidun Studio Photography will gladly offer you our services. A photoshoot has the power of re-energizing and empowering people, giving them a new purpose in life. And even after your kids are grown and have families of their own, it’s never a bad idea for a couple photoshoot with your significant other. You will value these images tremendously as time goes on. I strongly suggest that you try to sneak out a few shots of the two of you during every family photoshoot. But just think about how precious it will be to have photos of only the two of you walking the path of life year after year. You may be wondering, why take the couple’s pictures, aka mom & dad, during a family photoshoot? These images may seem unnecessary for you, as the photoshoot is focused on the family group shots and photos of the kids. Anniversary photo sessions are all about the couple and their special bond of love. Anniversary photoshoots are your chance of somewhat reliving your wedding day and refreshing your vows. With every year, the couple grows more in love and closer to each other. It’s a great tradition to celebrate significant marriage milestones such as wedding anniversaries. Still, it’s always crucial for their spouses, not mentioning the amount of pleasant memories they will derive from this couple photoshoot. Some fathers-to-be may not be as ecstatic about the maternity photo session. There are so many opportunities for a creative maternity photoshoot that highlights the beginning of a new life. Maternity pictures are taken either in a studio or out in nature. A carefully selected venue can really help to take your wedding portraits to the next level. Each wedding venue offers something unique to the couple, and all they have to do is choose the location that truly represents them as a couple. Nowadays, weddings are more customized, and couples tend to personalize their big day according to their unique preferences. They can be big or small as in elopements, ethnic weddings, and even 5-day weddings. WEDDING PHOTOSHOOTĮverybody knows that weddings run according to a specific schedule, but we must also not forget that not all weddings are the same. It’s always more memorable when they personalize the photoshoot with a particular theme, special outfits, or a meaningful location. The engagement photo session is a special time when the photographer captures the connection and unique bond between the couple. There are endless photoshoot ideas for engagement pictures. Some couples choose to capture their proposal pictures as well, and those are stunning and memorable moments. ENGAGEMENT PHOTOSHOOTĪn engagement photoshoot is often the first professional photo session you will have as a couple. Below, I’ve noted some of the most commonly captured life milestones. After all, it’s about celebrating the bond between two people in love. WHAT ARE THE DIFFERENT TYPES OF COUPLE’S PHOTOSHOOTS?Ĭouple’s photoshoots can and should be done at any age and without a special occasion motive. Irish Cream syrup is what gives this cold brew its unique flavor, so definitely don’t skip this ingredient! I purchased it in a pump bottle and enjoy a few pumps in my daily hot coffee as well. Any ice will do to keep this coffee drink cold, but we suggest cube-shaped ice and not crushed ice, which melts faster and will make your iced coffee watery. Chill your glasses in the freezer for at least 10 minutes before serving! The cold glass will help keep your iced coffee cold and your whipped cream from losing its foamy texture.I make my own cold brew (see my instructions in the How to Make Cold Brew section), but because it has become a popular beverage you can find plain cold brew coffee bottles in most grocery stores.Typically it takes about one minute to get a foamy texture if you are making only one serving, but up to five minutes if you are making a bigger batch of cream. Actual product packaging and materials may contain more or. Love Starbucks Drinks Try these copycat recipes More Fast Food Copycat Drink Recipes Starbucks Vanilla Sweet Cream Cold Brew Starbucks Cold Brew with Vanilla Sweet Cream Starbucks took its delicious nitro cold-brewed coffee and topped it off with sweet cream flavored with vanilla. I use an immersion blender for whipping the cream, however, a handheld mixer will also do the trick. Cold-Brewed Starbucks Coffee (Water, Coffee), Skim Milk, Sugar, Cream, Natural, Flavors. 200 item Here's a savory-meets-sweet refreshing beverage certain to delight: our signature, super-smooth cold brew, sweetened with a touch of caramel and topped with a salted, rich cold foam.For a creamy foam that holds its shape, use cold heavy cream and whip it in a cold bowl that has been chilled in the freezer for at least 10 minutes. Version numbers of XProtect, Gatekeeper, MRT, TCC and KEXT blocker data installed.Firmware, for all Mac models including those with T2 chips.SilentKnight and silnite report the following key security indicators: These three are available from their Product Page. You can also check versions installed and other security settings using LockRattler. If you want a command tool version of it, silnite should be ideal. My free app SilentKnight accesses the last of those and checks whether that Mac’s versions are current, and more. I also store an XML Property List containing this information on GitHub, which you are welcome to access for non-commercial purposes. I maintain lists of current versions on several pages here, for: As Apple doesn’t announce those updates, or detail which versions are current, there’s no official source for information. This article explains which of the items listed in CIS Apple macOS 10.15 Benchmark v1.0.0 – 04-06-2020 can be tackled and monitored using my free apps SilentKnight, LockRattler, and the command tool silnite.Ĭhapter 1 lists a series of scored benchmarks for macOS updates, security updates, etc., which rely largely on softwareupdate settings, and don’t actually verify whether updates installed are the latest released by Apple. There have been various security benchmarks and recommendations for securing Macs, of which one of the most widely used now comes from the Center for Internet Security. Also, elements with even atomic numbers are generally more common than their neighbors in the periodic table, due to favorable energetics of formation. Elements of higher atomic number than iron (element 26) become progressively rarer in the universe, because they increasingly absorb stellar energy in their production. The elements from carbon to iron are relatively more abundant in the universe because of the ease of making them in supernova nucleosynthesis. Lithium, beryllium, and boron, despite their low atomic number, are rare because, although they are produced by nuclear fusion, they are destroyed by other reactions in the stars. Remaining elements, making up only about 2% of the universe, were largely produced by supernovae and certain red giant stars. The abundance of chemical elements in the universe is dominated by the large amounts of hydrogen and helium which were produced during the Big Bang. Changing the given environment to Jupiter's outer atmosphere, where hydrogen is diatomic while helium is not, changes the molecular mole fraction (fraction of total gas molecules), as well as the fraction of atmosphere by volume, of hydrogen to about 86%, and of helium to 13%. As another example, looking at the mass fraction abundance of hydrogen and helium in both the Universe as a whole and in the atmospheres of gas-giant planets such as Jupiter, it is 74% for hydrogen and 23–25% for helium while the (atomic) mole fraction for hydrogen is 92%, and for helium is 8%, in these environments. However, the mole fraction is about 33% because only 1 atom of 3 in water, H 2O, is oxygen. Most abundance values in this article are given as mass fractions.įor example, the abundance of oxygen in pure water can be measured in two ways: the mass fraction is about 89%, because that is the fraction of water's mass which is oxygen. Volume fraction is a common abundance measure in mixed gases such as planetary atmospheres, and is similar in value to molecular mole fraction for gas mixtures at relatively low densities and pressures, and ideal gas mixtures. Abundance is measured in one of three ways: by mass fraction (in commercial contexts often called weight fraction), by mole fraction (fraction of atoms by numerical count, or sometimes fraction of molecules in gases), or by volume fraction. The abundance of the chemical elements is a measure of the occurrence of the chemical elements relative to all other elements in a given environment. Abundance at scales including the Universe, the Earth and the human body If you want to run Flameshot with the most cutting edge features, you can download a development version from here. 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They highlighted how their Point of Care Assist solution provides real-time information about patient care benefits to providers so they can better help members find high-quality, cost-effective healthcare. The organization is leveraging value-based, incentive relationships with providers that pay for better health outcomes and performance. Quality of care is also a priority at UnitedHealthcare. As an example, they touted that more than 4.5 million alerts were generated in 2021 by their remote patient monitoring platform, enabling faster responses to adverse health events. Plus, UnitedHealthcare has increasingly relied on data and technology to improve care. For example, advocate specialization has grown within specific communities and populations, enhancing support. The company has focused on improving the member experience through better navigation and advocacy programs. UnitedHealthcare has grown its Medicare Advantage enrollment by an average of 13% annually over the past five years, in part due to growth in Medicare Advantage in general. Additionally, thanks to its relationship with Optum, UnitedHealthcare can leverage technology, data, and analytics to improve health outcomes and lower the overall cost of care. Plus, new advocacy programs assist members during their care journey. They’re doing this through home-based care and expanding the ways individuals can access the healthcare system. UnitedHealthcare is working to simplify that experience, creating personalized experiences for individuals and providers. The Harmony plan touts a better experience that leverages technology and a provider network based on provider performance and efficiency.Īs CVS pointed out in their investor presentation, the healthcare system can be difficult to navigate for patients. They’re doing that with innovative plan designs – like virtual primary care and their new Harmony plan in California. UnitedHealthcare is the company’s health insurance arm.įor UnitedHealthcare, that organizational structure helps them achieve their strategic goal of delivering affordable health care. Optum, at its core, focuses on health care delivery. The company operates two distinct businesses, Optum and United Healthcare. With the largest market share among US insurers, what UnitedHealth Group says at their annual investor days can have an outsized impact on the future of the health insurance industry.īefore we dive into the presentation, a quick note about UnitedHealth’s structure. Here’s a roundup of those five insurer investor meetings and what they tell us about the future of health insurance. Discussions centered around technology, value-based care, social determinants of health, virtual care, and an increased focus on the consumer. Five insurers recently completed their investor meetings. Investor meetings offer a wealth of information about a company’s strategy and short and long-term plans. The main gun group: 4 triple 406mm/50 times the diameter of MK7 type of naval gunĭisplacement: 65000 tons row, full row of 70500 tons Hailed as the pinnacle of the United States at the expense of the speed of the emphasis on fire and protective performance. The design scheme and even affect the British drafted in 1939 for "Lion" program and "brave" number two battleships design. Although the speed is reduced, but the shape is bigger, the armor is heavier, the firepower is stronger. This level is Iowa class battleship and South Dakota class battleship inheritance version. Is the United States Navy design last class battleship. Montana class battleship:The United States Navy during the second world war plans to build, but never actually built a battleship. Please try again later.īecome an officer in the Subsim Navy here and have your download limit increased to 25, 35 or even 60 a day! Click here to join.Ī website this big uses a lot of bandwidth and needs a really powerful server to stay online day after day, for 20 years. Then the Downloads section is experiencing heavy load volumes and has been You are registered and getting this message, You must be registered with this forum to download files. Main | Legacy Downloads | Utilities | Category Tree | Stats | Search Or switching to Microsoft Edge browser or Firefox to complete the download. Try turning off the ad-blocker or whitelisting in your ad-blocker extension If you are experiencing trouble downloading, it could be due to an ad-blocker or extension in your Chrome browser. 12 At this immature B‐cell stage, the cells are first tested for tolerance to self‐antigens. After functional V‐(D)‐J recombination of IgH and IgL chain genes, the resulting immature naïve B‐cells transcribe the IgH and IgL genes, and are able to produce IgD and IgM immunoglobulin isotype by alternative splicing of the transcript to fuse the μ and δ exon to the IgHJ exon, respectively. Therefore, each mature antigen‐naïve B‐cell typically expresses BCR sequences encoding the heavy‐ and light‐chains. 11 When a cell has successfully rearranged a IgH gene, the B‐cell begins to rearrange the light‐chain genes. Likewise, each IgL chain locus encodes multiple distinct copies of λ chain and κ chain variable (V) gene segments and joining (J) gene segments. Class‐switch recombination (CSR) can also occur during B‐cell activation, which is a chromosomal deletion process leading to the expression of a different antibody isotype. Somatic hypermutation (SHM) can occur during B‐cell activation, in which mutations are introduced into the V‐(D)‐J region of the BCR. The resulting B‐cell receptor (BCR) may be expressed as both surface IgD and IgM on naïve B‐cells through alternative splicing. Similarly, V‐J recombination occurs in the light‐chain. During B‐cell development, V‐D‐J recombination occurs to produce a functional heavy‐chain. B‐cells are generated from haematopoietic stem cells. Schematic diagram of the processes of B‐cell differentiation and selection, annotated with known human genetic modifiers of the process and the point in selection at which they are thought to act. 8 These pre‐B‐cells are selected for functional heavy‐chain by IgV‐D‐J expression and IgH assembly by pairing. 7 Further mechanisms that contribute to the generation of diversity include alternative IgHD reading frames and IgHD–IgHD fusions. This results in sequence diversification at the junctional regions. 5, 6 The imprecise joining of the V, D and J gene segments leads to the introduction of random deletions and insertions of nucleotides through exonucleases and terminal deoxynucleotidyl transferase (TdT), respectively. This process of site‐specific recombination is highly orchestrated and mediated by recombination activating genes 1 (RAG1) and 2 (RAG2). This encodes the protein sequence for the antigen‐binding region of the IgH protein 2, 4 (Fig. 2 During B‐cell development, functional immunoglobulin genes are generated through the deletion of intervening DNA, 3 creating a IgH gene containing one V, one D and one J gene (VDJ). The germline immunoglobulin heavy‐chain (IgH) gene locus encodes multiple distinct copies of the variable (V), diversity (D) and joining (J) genes, which are separated by over 100 kbp from a much smaller number of DNA segments encoding the constant genes. 1ī‐cells develop from haematopoietic stem cells and differentiate through several maturation stages in the bone marrow. Defects in B‐cell development and function can lead to a breakdown of immunological tolerance and therefore autoimmune diseases, which affect approximately 1 in 12 people worldwide. B‐cells have the potential to recognize a vast array of pathogens, but diversity in the B‐cell repertoire comes at a price, namely that there is a potential for autoreactivity in a subset of B‐cells. BCRs are the membrane‐form of antibodies and are generated through DNA recombination. B‐cell clones selectively expand following antigen recognition by B‐cell receptors (BCRs). It has been hypothesized that these differences may signify differences in B‐cell tolerance however, the mechanisms and implications of these defects are not clear.ī‐cells produce antibodies and are crucial for effective immunity. B‐cell clones have effectively been characterized and tracked between different tissues and blood in autoimmune disease. Interestingly, some common repertoire defects are shared between diseases, such as elevated IGHV4‐34 gene usage. These autoimmune diseases exhibit significantly skewed B‐cell receptor repertoires compared with healthy controls. Here, we discuss the current research using B‐cell antibody repertoire sequencing in three polygenic autoimmune diseases where there is good evidence for a pathological role for B‐cells, namely systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis. The advent of technologies, such as whole‐genome sequencing, offers the chance to link abnormalities in the B‐cell antibody repertoire to specific genomic variants and polymorphisms. It can address key questions, including: (i) how the B‐cell repertoire differs in health and disease and (ii) if it does differ, the point(s) in B‐cell development at which this occurs. High‐throughput sequencing of the DNA/RNA encoding antibody heavy‐ and light‐chains is rapidly transforming the field of adaptive immunity. |
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